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Focusing Fields

R & D Strategy

Compared to large biomolecules, small molecules (MW < 1,500) typically have stronger abilities to penetrate biological barriers, more accessible targets, and can simultaneously act on multiple proteins. Small molecule drugs provide a cost-effective treatment option for global patients due to their more convenient methods of administration, higher stability and convenience in storage and transportation, as well as lower production and drug costs.

However, due to the smaller contact area with target proteins and fewer interatomic interactions, small molecules require more creative structural design to achieve the desired biological specificity and drug-like properties. Tyligand Bioscience aims to create highly selective small molecule ligands with multiple and precise regulation of signal protein phosphorylation levels, relying on the team's in-depth understanding of biological targets and rich experience in synthetic chemistry, providing more effective, safer, more convenient, and more economical solutions for patients to restore health.

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Cancers

Focus on carcinogenesis and tumor tissue characteristics

The phenotypic heterogeneity and evolutionary capacity of malignancies pose great challenges to the task of curing advanced cancers with drugs targeting a single signaling pathway. First, tumor cells have basically the same genome and functions as normal cells, and use normal growth and anti-apoptosis mechanisms to proliferate indefinitely, making it difficult for the immune system to recognize them. The mechanistic dependence of the human immune system on homeostasis and the complexity of multiple regulation provide opportunities for tumor escape.

At the same time, the organized tumor cells create a microenvironment suitable for growth, providing nutrient flow, waste disposal, information transmission and other services and structural support, as well as border defenses that hinder immune cell intervention and drug penetration. Therefore, the drug resistance of targeted therapy and the universality of immunotherapy have become the main challenges of cancer research in the world today.

We focus on the carcinogenesis mechanism and tumor tissue characteristics at the molecular level, and are committed to discovering drugs that can precisely and multi-pathway regulate the conduction of oncogenes and their expressed protein signals, providing patients with effective, safe, convenient and accessible treatment options. 

Autoimmune Diseases

Autoimmune diseases are usually manifested by an overactive or disordered immune system that attacks and damages one's own tissues. Such diseases include: Rheumatoid Arthritis, Ankylosing Spondylitis, Systemic Lupus Erythematosus, Inflammatory Bowel Disease (IBD), Multiple Sclerosis, Type I Diabetes, Psoriasis, etc. With the development of immunology science, the popularization of knowledge and the improvement of diagnosis level, the diagnosis rate of autoimmunity is increasing year by year. In addition, changes in living habits and living environment, as well as the extension of the average life expectancy of human beings, make the incidence of autoimmunity second only to cardiovascular diseases and tumor diseases. These chronic diseases have had a great impact on human health and people's quality of life.
Autoimmune diseases are usually manifested by an overactive or disordered immune system that attacks and damages one's own tissues. Such diseases include: Rheumatoid Arthritis, Ankylosing Spondylitis, Systemic Lupus Erythematosus, Inflammatory Bowel Disease (IBD), Multiple Sclerosis, Type I Diabetes, Psoriasis, etc. With the development of immunology science, the popularization of knowledge and the improvement of diagnosis level, the diagnosis rate of autoimmunity is increasing year by year. In addition, changes in living habits and living environment, as well as the extension of the average life expectancy of human beings, make the incidence of autoimmunity second only to cardiovascular diseases and tumor diseases. These chronic diseases have had a great impact on human health and people's quality of life.
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There is a complex immune system in the human body to defend against the invasion of foreign substances. Foreign bodies such as viruses, bacteria, transplanted organs or autologous lesions will be recognized by the immune system and initiate a series of rejection and clearance mechanisms. Under normal circumstances, the immune system will not or only have a very weak autoimmune response to biomolecules in its own tissues. However, due to various reasons, if the autoimmune reaction reaches a certain intensity and the attack on the normal tissues and organs of the body manifests as clinical symptoms, it is collectively referred to as an autoimmune disease.

Due to differences in individual genetic factors and growth environments, the factors leading to the pathogenesis of autoimmune diseases, that is, the imbalance of immune cell functions, are very complicated, but they are mainly related to the appearance of self-antigens. If the immune system resists foreign invading pathogens, such as bacteria, if the antigenic components targeted are the same or similar to the antigenic components of the human body's own cells, the resulting antibodies will also produce an immune response to the own tissues. In addition, certain body components hidden in the body that are normally insulated from the immune system can also become antigens that trigger autoimmune responses when released due to trauma or other reasons.

Traditional treatments rely on drugs that reduce the activity of the immune system, such as corticosteroids, nonsteroidal anti-inflammatory drugs (NSAIDS), and antipurine metabolizers such as methotrexate. A new generation of macromolecular biological drugs selectively blocks the signal transmission of pro-inflammatory factors and their receptors in the body. The side effects and scope of application of these drugs limit their application and effect. We work closely with medical professionals to discover unmet patient needs and actively develop new drugs that act on novel mechanisms and are highly selective for the treatment of autoimmunity.

Causes of cancer

  • The causes of cancer are complex, but they all manifest as the uncontrolled growth of cells in the body. In order to maintain the normal operation of the human body, the process of growth, maturation, reproduction and death of each tissue cell has a strict control mechanism. The occurrence of tumor diseases starts from the collapse of this orderly process, leading to abnormal differentiation of local cells, unlimited proliferation, and escape from the monitoring and hunting of the human immune system until it infiltrates into the surrounding tissues and induces its irreversible growth. Restricts the formation of blood vessels that grow to provide the needed oxygen and nutrients, and metastasize to other organs through the vascular or lymphatic system to form new tumors far away from the primary lesion.

    Genetic changes that lead to cancer tend to involve three main types: mutations in proto-oncogenes, failure of tumor suppressor genes, and loss of DNA repair genes. These changes are often referred to as the "driver genes" of cancer. Proto-oncogenes are originally involved in normal cell growth and division. However, when these genes are altered in certain ways to become overactive, they can become oncogenes, driving cells to grow and survive out of control. The normal function of tumor suppressor genes is to be involved in controlling the growth and division of cells. When they are altered, disabled or their expression inhibited, cancerous cells divide and proliferate in an uncontrolled manner. The original function of DNA repair genes is to direct the repair of damaged genes. When the function of these repair genes is lost, the errors in the mutated genes are passed on and can lead to cancer.